Review
Sep 2026
Biophysical and molecular mechanisms of lysosomal mechanoresilience: Membrane tension, TMEM63A, and cellular injury.
Lysosomal membrane failure contributes to cellular injury by disrupting degradation, metabolism, immune signaling, and compartmental integrity, yet the physical principles that determine whether a mechanically loaded lysosome adapts or ruptures remain incompletely resolved. This review integrates biophysical and molecu...
R. S. Hamad, A. El-kott, Sally Negm et al.
· Progress in Biophysics and M... · 0 citations