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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Eloise Hudry

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Open access Aug 2026

Long-read target enrichment sequencing for rAAV integration site analysis in engineered clones with targeted viral insertion

Together, the engineered clonal controls and optimized LR-TES provide reference material and a technical framework supporting rAAV ISA in safety evaluation, particularly when high structural resolution and specificity are needed to interpret predominant integration events.

Erica Coratella, Myriam Lemmens, Mevion Oertli et al. · 0 citations
Aug 2026

Leveraging host cell modulators of adeno-associated vectors transduction to tailor viral biodistribution.

A novel approach to detarget liver transduction is developed by transiently downregulating the expression of key entry factors in this tissue using GalNac-siRNAs prior to AAV9 administration, which blunted hepatic transduction but also redirected the vector to other transduction-permissive tissues.

K. Kubek-Luck, J. Velazquez, Xiao-Rui Yao et al. · 0 citations

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