Ellen F. Gregory

Muscular dystrophy–associated lamin variants disrupt cellular organization through a nucleolar-ribosomal axis

Emery-Dreifuss muscular dystrophy (EDMD) arises from mutations in nuclear lamins or emerin. Current pathological models emphasize defective nuclear mechanics and transcriptional regulation, yet these mechanisms cannot explain how lamina defects propagate across the cell to produce the complex pathology of laminopathies...