Mesenchymal Stem Cell-Derived Paracrine Products as Senotherapeutic Interventions for Skin Photoaging: A Preclinical Systematic Review of the Senescence-SASP Axis
Chronic ultraviolet (UV) exposure induces oxidative stress, mitochondrial dysfunction, DNA damage, and cell cycle arrest through the p53/p21^CIP1^ and p16^INK4a^ pathways, contributing to cellular senescence and the development of the senescence-associated secretory phenotype (SASP). Objective: This study aimed to synt...