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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Elisa Uliassi

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Review Open access Aug 2026

Targeting IGF2BP3 in Cancer: From Molecular Structure and Biology to Early Drug Discovery

This review describes the structural organization of IGF2BP3, the molecular basis of RNA recognition, and the mechanisms underlying its dysregulation across human cancers and discusses emerging therapeutic approaches, including direct inhibition of IGF2BP3–RNA interactions and indirect strategies that rewire IGF2BP3 expression or activity through epigenetic, epitranscriptomic, and signaling pathways.

Elisa Uliassi, M. Bolognesi, K. Scotlandi et al. · 0 citations

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