Open access
Sep 2026
MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness
Extrachromosomal DNA (ecDNA) comprises megabase-sized circular DNA elements that frequently carry oncogene amplifications, driving aggressive tumour phenotypes, therapeutic resistance and poor clinical outcomes across many cancers1, 2, 3–4. Although ecDNA is thought to arise from canonical double-strand break repair, t...
David Billing, Monica Selvaraj, M. E. Kelley et al.
· Nature · 1 citation