Eilley W. Barron

Targeting microtubule dynamics with mebendazole slows disease progression in ADPKD mice

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder and is primarily caused by mutations in PKD1 or PKD2. The disease is characterized by the progressive development and enlargement of fluid-filled renal cysts over decades. Microtubules (MTs) are highly dynamic cyto...