Author

Eiichiro Nishi

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Open access Sep 2026

Nardilysin regulates Slc2a2 expression via an ISLET1-dependent enhancer mechanism in pancreatic β-cells

GLUT2 (Slc2a2) is a key glucose transporter in pancreatic β-cells, and its reduced expression is closely linked to defective glucose-stimulated insulin secretion (GSIS) and diabetes. We previously reported that pancreatic β-cell–specific nardilysin (NRDC)-deficient mice (BetaKO) exhibit a severe diabetic phenotype with...

Kiyoto Nishi, Narangerel Ganbaatar, Mikiko Ohno et al. · Biochemistry and Biophysics... · 0 citations

Open access Aug 2026

Nardilysin fine-tunes the mammalian circadian clock through selective modulation of PER2 function

Circadian rhythms in mammals are generated by negative feedback loops, in which CLOCK and BMAL1 bind to E-box to activate transcription of Period (Per) and Cryptochrome (Cry) and the E-box-dependent transactivation is inhibited by PER and CRY proteins. Although the core transcriptional feedback loop of the circadian cl...

Yoshinori Hiraoka, R. Nunokawa, Mikiko Ohno et al. · bioRxiv · 0 citations

Sep 2026

Identification of a small-molecule inhibitor of nardilysin and its pharmacological effects on transcriptional regulation and inflammatory arthritis.

Nardilysin (NRDC) is a zinc metallopeptidase of the M16 family that participates in diverse biological processes, including ectodomain shedding and antigen processing. NRDC also functions as a transcriptional coregulator, and this coregulatory activity depends on its metallopeptidase catalytic function. However, small-...

Yasutaka Amano, Kiyoto Nishi, Hazuki Sano et al. · Biochemical Pharmacology · 0 citations