Staphylococcus aureus
prosthetic joint infections (PJIs) are broadly considered incurable, and clinical diagnostics that guide conservative vs. aggressive surgical treatments don’t exist. Understanding the human T cell response to chronic
S. aureus
osteomyelitis may lead to improved patient outcomes and info...
Motoo Saito, Katya A. McDonald, Alexander Grier et al.· Communications Medicine· 0 citations
Staphylococcus aureus is the leading cause of implant-associated osteomyelitis. It has a high recurrence rate, a low post-operative cure rate, and can lead to sepsis, multiorgan failure, and death. This indicates a need for future innovation in therapeutics and vaccines. With our humanized mouse model, we aimed t...
Katya A. McDonald, Motoo Saito, Himanshu Meghwani et al.· Journal of Immunology· 0 citations
Osteoarthritis (OA) is a significant clinical problem that places a substantial burden on both patients and the healthcare system. Characterized by progressive cartilage degeneration, synovial inflammation, and subchondral bone remodeling, OA is a rapidly growing and increasingly studied disease affecting millions arou...
Sarah Bergren, Hannah Shelby, Julian Wier et al.· Biomedicines· 0 citations
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