Nelfinavir Synergizes with Cisplatin and Promotes GSDME-Associated Lytic Cell Death in Platinum-Resistant Ovarian Cancer Cells
Background/Objectives: Platinum resistance limits the efficacy of ovarian cancer treatment and arises through multiple mechanisms, including enhanced DNA repair, activation of stress responses, and increased survival signaling. Nelfinavir (NFV), an HIV protease inhibitor with reported anti-tumor activity, is a candidat...
Benjamin N. Forgie, R. Prakash, Desiree Marno et al.
· Pharmaceuticals · 0 citations