Author

E. Kizana

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Open access Aug 2026

High-throughput screening in hiPSC-cardiac models reveals cardiomyocyte-specific cell cycle regulatory mechanisms

A dual-reporter and a high-throughput image-based pipeline are developed and a cardiomyocyte-selective pro-proliferative compound is identified as GDC-0339, uncovering cardiomyocyte-specific mechanisms governing the cell cycle that are potentially druggable.

Francesca Butera, Bryce Hassett, Rachel Morris et al. · bioRxiv · 0 citations

Open access Jul 2026

Identification of AAV Vector Integration Sites in Primary Human and Macaque Hepatocytes in vivo, and Analysis of Oncogenic Risk.

RAAV integration patterns in primary human hepatocytes xenografted into FRG mouse livers and in hepatocytes from cynomolgus macaques following systemic rAAV administration support a low oncogenic risk profile for the evaluated vector while reinforcing the value of direct human liver integration analyses to refine risk...

S. Scott, C. Hallwirth, Natsuki Sasaki et al. · Molecular Therapy · 0 citations