E. Vassos

Genetic architecture of treatment-resistant schizophrenia across East Asian and European cohorts: insights from GWAS, TWAS, and synaptic pathway analyses

Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study

Findings provide proof-of-concept for the utility of pPGSs in psychiatric research, suggesting both genetic contributions to trauma exposure and GxE effects on psychosis risk, as well as supporting pathway-specific contributions beyond general polygenic risk.

Prolonged Childhood and Adolescent Loneliness in First-Episode Psychosis: Synergistic Polygenic Effects and Functional Outcomes.

Prolonged CAL is linked to higher risk of FEP, preferentially affective psychosis in females, poorer functioning, and developmental potentiation of polygenic liability.

The Neuropsychiatry of 22q11.2 Deletion Syndrome: An Electronic Health Records Study.

In the largest electronic health records study of 22q11.2DS to date, a profound neuropsychiatric burden is revealed and the potential of routinely collected health data to advance understanding of rare disorders is demonstrated.