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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

E. Ünal

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3 papers indexed here

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Open access Sep 2026

A role for selective ER autophagy in gametogenic rejuvenation revealed by high-throughput lifespan profiling

During mitotic growth, Saccharomyces cerevisiae cells age by dividing asymmetrically, producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and fully resets precursor cell lifespan, even for replicatively aged cells...

Silvan Spiri, T. Sing, Nhi Phung et al. · 0 citations
Open access Aug 2026

Prefoldin function links meiotic chromosome segregation with cellular remodeling and reveals tubulin sensitivity of the meiotic spindle

Faithful chromosome segregation is essential for producing viable gametes during meiosis, a specialized type of cell division relative to mitosis. Here we identify Gim3, a subunit of the ubiquitously expressed and conserved prefoldin complex, as a critical regulator of meiotic but not mitotic chromosome segregation in...

Naohiro Kuwayama, Benjamin S. Styler, Bojana Stekovic et al. · 0 citations
Open access Oct 2026

The UPR drives gametogenesis via an unexpected response, coordinating translation and ER structure.

It is found that the endogenous UPR that precedes meiosis in budding yeast is required for gamete production but diverges dramatically from previously defined UPR outputs, with only a few characterized UPR targets induced, and mildly.

Constantine Bartolutti, Alena L. Bishop, Yanzhe Ma et al. · 0 citations

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