Exploring the antidepressant-like effects of cannabidiol and/or temozolomide in female mice with induced glioblastoma.
Temozolomide (TMZ), the gold standard drug used for the treatment of glioblastoma, is known to affect healthy brain proliferating cells, inhibiting adult hippocampal neurogenesis. Since most antidepressants mediate their beneficial effect through this process and given the large proportion of glioblastoma patients with...