Author

E. Stelow

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Sep 2026

Abstract B097: Plectin promotes an aggressive phenotype and represses anti-tumor immunity in pancreatic cancer

Pancreatic adenocarcinoma (PDAC) is an abysmal disease, with a poor clinical outcome, largely due to limited life-extending treatments for patients. Notoriously, PDAC displays a T cell-suppressive tumor microenvironment where underlying molecular mechanisms that lead to this phenotype remain poorly understood. To unr...

Kimberly A. Kelly, Cody L. Wolf, Roxanne K. Ruiz et al. · Cancer Research · 0 citations

Open access Aug 2026

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer

Plectin is identified as a biomarker of aggressive disease in PDAC, with high plectin expression associated with decreased T cell infiltration, and anti-CSP treatment reinstates antitumor immunity and decreases tumor volume in vivo.

Cody L. Wolf, Roxanne K. Ruiz, Sokchea Khou et al. · Frontiers in Immunology · 0 citations