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Author

E. Solje

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Review Open access Aug 2026

Live brain biopsy during CSF shunt surgery for precision diagnostics and multi-omic research

Diagnostic testing and neurosurgical management involving CSF shunting in patients with idiopathic normal pressure hydrocephalus (iNPH) offers a unique, ethically sustainable opportunity to study the aging human brain. The common co-occurrence of neurodegenerative pathologies such as amyloid-β plaques and neurofibril...

Heikki E. M. Lukkarinen, A. Luikku, Antonios Dougalis et al. · 0 citations
Open access Aug 2026

C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expression

Summary C9orf72 hexanucleotide repeat expansion (C9-HRE) is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (FTD). However, approximately half of the FTD patients are sporadic without a clear genetic background. To compare characteristics of microglia from different FTD subtypes, we g...

Hannah Rostalski, Tomi Hietanen, Dorit Hoffmann et al. · 1 citation

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