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Proteinuria as the cause of early dose modification in Japanese patients with metastatic colorectal cancer treated with fruquintinib: a multicenter real-world study.
BACKGROUND Fruquintinib has demonstrated survival benefits in patients with previously treated metastatic colorectal cancer (mCRC) in phase III trials. However, real-world data in Japanese patients remain limited. This study evaluated the effectiveness and safety of fruquintinib in routine clinical practice. METHODS...
Prognostic impact of circulating tumor RAS and BRAF mutation dynamics in patients with metastatic colorectal cancer
Summary Post-treatment alterations in circulating tumor DNA (ctDNA) hold potential for refining treatment strategies in metastatic colorectal cancer (mCRC). In this multi-institutional study of 1,391 patients from the SCRUM-Japan GOZILA platform, we evaluated the prognostic significance of post-treatment rat sarcoma vi...