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Author

E. Schneider-Futschik

2 papers indexed here

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Open access Sep 2026

Temporal N-terminomics analysis reveals proteome remodeling following brensocatib-mediated cathepsin C inhibition in promyeloblast cells

Cathepsin C (CatC) is known to activate neutrophil serine proteases (NSPs) involved in innate immune function, although its broader impact on cellular proteolytic networks remains poorly defined. Here, we characterized the proteolytic landscape of HL-60 neutrophil progenitor cells following treatment with the CatC inhi...

Yi-Min Zhu, Stephan Luedtke, Bang-Yan Xu et al. · 0 citations
Open access Sep 2026

Microbial modulation of CFTR modulator exposure: In vitro interactions between elexacaftor-tezacaftor-ivacaftor and pulmonary and gut bacteria from people with cystic fibrosis.

BACKGROUND Elexacaftor-tezacaftor-ivacaftor (ETI) has transformed cystic fibrosis (CF) care, but individual responses remain variable. Although longitudinal studies indicate that ETI reshapes lung and gut microbiota, the contribution of direct drug-microbe interactions remains unclear. We used an in vitro pharmacomicro...

P. Boulic, Cyril Leven, Dan-Ni Li et al. · 0 citations

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