Temporal lobe epilepsy (TLE) is associated with altered functional connectivity, yet its effects on connector hubs, regions supporting long-range and inter-network communication, remain poorly understood. We used SParsity-based Analysis of Reliable k-hubness to characterize connector hub reorganization in unilateral TL...
Arielle Dascal, Édouard Delaire, A. Ngo et al.· bioRxiv· 0 citations
A surface-intrinsic formulation of hippocampal unfolding is introduced in which geometry, intrinsic coordinates, and correspondence are defined directly on subject-specific surface manifolds, enabling topology-preserving alignment and more accurate characterization of inter-individual variability in health and disease.
J. DeKraker, D. Bansal, M. Snyder et al.· bioRxiv· 0 citations
These findings provide robust evidence that multiscale MRI profiling can identify FCD signatures and contribute to in-vivo subtyping and the novel use of myeloarchitecture profiling and contextualization with macro-scale brain gradients provides new avenues to understand intracortical alterations and the embedding of F...
E. Sahlas, Judy Chen, Arielle Dascal et al.· bioRxiv· 0 citations
Multi-site findings demonstrate marked thalamic circuit fragmentation in TLE, and robustly showed subdivision-specific effects, which point to both mesiotemporal co-lateralization as well as broader system-level involvement.
Rui Ding, K. Xie, Judy Chen et al.· bioRxiv· 0 citations
A hypometabolic gradient is identified in TLE, which covaries with cytoarchitectonic organization, microstructural changes, and hippocampal-neocortical interactions and provides a biologically grounded framework for precise surgical planning, emphasizing that targeting severe hypometabolism may optimize prognosis.
J. Mo, F. Fadaie, J. Lam et al.· medRxiv· 0 citations
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