Anti-RBD Single-Chain Variable Fragments Library (scFv Library) Generation toward the Development of a Diagnostic Platform for SARS-CoV-2.
A mouse-derived single-chain variable fragment phage display library is generated against the RBD of the SARS-CoV-2 spike protein to highlight the potential utility of these scFvs as candidate reagents for the development of improved diagnostic platforms and as scaffolds for next-generation monoclonal antibody-based therapeutics.