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E. S. Engdal

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Open access Sep 2026

Engineering human endogenous retrovirus-K for improving immunogenicity and broad cancer targeting

HERV-K (HML-2) is the most studied transcriptionally active endogenous retrovirus in human cancers, yet immune tolerance and incomplete mechanistic understanding have impeded its clinical use as an immunotherapy target. We hypothesized that rational engineering of the HERV-K envelope putative immunosuppressive do...

M. D. Müller, L. Neukirch, E. Ragonnaud et al. · 0 citations
Open access Jul 2026

Hybrid quantum-classical de novo design of MHC-binding peptides

Deep generative models have become a leading approach for designing therapeutic molecules, yet efficiently exploring vast biomolecular sequence spaces remains difficult, particularly for targets with limited training data. The prior distribution that seeds a generative model shapes which regions of sequence space it ex...

E. S. Engdal, Jonathan Funk, O. Bacarreza et al. · 0 citations

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