A critical role is uncovered for intrinsically disordered regions (IDRs) in activating NLRP1, NLRP3, and NLRP14 inflammasomes, suggesting that targeting the dynamics of phase transitions could open novel therapeutic avenues for treating inflammatory and autoimmune diseases.
Teresa Nava-Ramírez, C. Cuevas-Velazquez, Alejandra A. Covarrubias et al.· Frontiers in Immunology· 0 citations
Results suggest that R. microplus may produce putrescine through an alternative route involving agmatine, thereby bypassing the canonical ornithine decarboxylation pathway, and support the existence of a previously unrecognized branch of polyamine metabolism in ticks.
R. Cossío-Bayúgar, E. Miranda-Miranda, Michael F. Dunn et al.· Scientific Reports· 1 citation
Overall, structural and functional analysis of CldA showed that it diverges from canonical GH13_2 CGTases by lacking C-terminal DE domains, shifting its intramolecular transglycosylation specificity toward hydrolysis through an intriguing starch concentration-dependent product-length mechanism.
Beatriz Velazquez-Cruz, Montserrat Romero-Jiménez, Yasel Guerra et al.· The FEBS Journal· 1 citation
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