Author

E. Mendenhall

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Open access Sep 2026

Discrepancies between ChIP-seq and CUT&Tag histone mark profiles are explained by GC content and chromatin accessibility

Chromatin profiling methods, such as ChIP-seq (chromatin immunoprecipitation followed by sequencing), are used to characterize the genomic localization of DNA-associated proteins. While ChIP and ChIP-seq have been used for decades, an orthogonal approach, CUT&Tag (Cleavage Under Targets and Tagmentation), is gaining po...

Eduardo Modolo, Lauren Patel, O. Ram et al. · bioRxiv · 0 citations

Open access Aug 2026

Trex-QTL: A mixture-model for identification of genetic effects with global effects on molecular phenotypes

While thousands of cis expression quantitative trait loci (cis-eQTLs) have been reliably identified, detecting trans-eQTL effects has proven to be challenging due to insufficient statistical power, lack of comparable tissues and cohorts, and low reproducibility across studies. Here, we present Trex-QTL, a novel trans-e...

Cynthia Wu, Andrey V. Bzikadze, Tian-Yao Xu et al. · bioRxiv · 0 citations