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Author

E. Meese

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Open access Aug 2026

Ex vivo activation unmasks a sex-convergent, exhaustion-associated CD8+ T cell expansion in Parkinson’s disease

Parkinson’s disease (PD) affects an estimated 6.4 million men and 5.3 million women worldwide, and still lacks a validated peripheral biomarker. Brain tissue is inaccessible in living patients, making peripheral blood an attractive alternative, but existing studies have profiled immune cells almost exclusively as stati...

Friederike Grandke, Caroline Diener, Bianca Becher et al. · 0 citations
Open access Sep 2026

miRNA Isoform Spectrum Expansion by Overexpression May Affect Target Gene Silencing.

MicroRNAs (miRNAs) regulate gene expression primarily through translational inhibition and mRNA degradation. Their functional complexity is increased by the presence of various mature isoforms (isomiRs). These isomiRs add diversity to miRNA targeting and regulation, yet their impact on cellular systems remains insuffic...

Fabian Kern, Martin Hart, Lena Krammes et al. · 0 citations
Open access Sep 2026

Temporal lymphatic tissue destruction and impairment of de novo T cell responses after an acute virus infection

The results highlight the complex interplay between virus infections, immune responses, and tissue integrity, challenging the common assumption that hosts fully recover their pre-infection homeostatic health state directly after an acute virus infection is controlled.

Paula Cebollada Rica, S. López-Serrano, Yannick O. Alexandre et al. · 0 citations

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