Open access
Aug 2026
The cost of persistent alarm: temporal transcriptional reprogramming of macrophages from acute activation to chronic immune suppression by day 11
It is shown that chronic inflammatory signaling can ultimately trigger a profound coordinated negative-feedback program consistent with a reduced immune recognition and defense pathway signatures, and offers deeper insights into how chronic inflammation impairs host defenses against viral and tumor cells.
E. Mazzio, A. Barnes, R. Badisa et al.
· Frontiers in Immunology · 0 citations