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Author

E. Mackow

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Open access Jul 2026

Single-cell analysis of Powassan virus-infected brains reveals age-dependent neuroinflammatory crosstalk and progressive Alzheimer’s-like APP/Aβ accumulation

ABSTRACT Powassan virus (POWV) causes lethal encephalitis in the elderly and long-term neurological sequelae in survivors. Mirroring human disease, POWV strain LI9 directs age-dependent lethality in C57BL/6 (B6) mice, resulting in spongiform encephalitis, gliosis, and inflammatory cytokine/chemokine responses in the CN...

M. R. D. de Souza, M. Lindner, Megan Mladinich-Valenti et al. · 1 citation

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