The advent of pan-RAS and allele-specific inhibitors in clinical trials have created an urgent need to understand how RAS inhibition remodels the pancreatic immune microenvironment and alters anti-tumor immunity, to guide rational combinations with immunotherapy.
We used a murine model with pancreas-specif...
Rashmi J. Kumar, E. Lasse-Opsahl, Lauren Gerbereux et al.· Cancer Research· 0 citations
Notch is a contact-dependent signaling pathway that plays critical roles in spatiotemporal patterning during embryogenesis. Beyond its role in development, Notch signaling regulates tissue patterning in adult organs in response to tissue injury or cancer. In the context of cancer, the role of Notch signaling has been...
Allison C. Bischoff, Wei Yan, Carlos E. Espinoza et al.· Cancer Research· 0 citations
Pancreatic ductal adenocarcinoma (PDA) exhibits marked organotropism, with the liver and lung representing the most common sites of metastatic recurrence. While PDA most often metastasizes to the liver, patients with only lung metastasis have a better overall prognosis, highlighting a role for both tumor-intrinsic pr...
E. Lasse-Opsahl, Daksh Thakkar, Julie M. Clark et al.· Cancer Research· 0 citations
It is suggested that pharmacologic and genetic KRAS inhibition differentially remodel the intratumoral T cell compartment, whereas both induce similar T cell changes within the liver premetastatic niche.
Lauren Gerbereux, Rashmi Kumar, E. Lasse-Opsahl et al.· Cancer Research· 0 citations
A GSTT1HighCD133High stem-like subpopulation in metastatic PDA is identified and an FGFR-dependent signaling axis that sustains this state is identified, representing a potential therapeutic vulnerability.
Delgado Herrera Deborah de la Caridad, Alejandro Arroyo Roman, Riyan N. Campbell et al.· Cancer Letters· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
