Sicyoidochytrium minutum DNA virus (SmDNAV) was isolated several years ago from a protist host of family Thraustochytriaceae of the class Labyrinthulomycetes. This virus shared little similarity to other viruses in gene content and protein sequences, albeit seemingly belonging to the phylum Nucleocytoviricota. By exten...
N. Yutin, Y. Wolf, M. Krupovic et al.· bioRxiv· 0 citations
It is hypothesize that the RNA world was, actually, an ‘RNA-peptide world’, in which, from the earliest stages of evolution, evolving RNA molecules interacted with short random peptides synthesized in a non-templated manner, which could drive the evolution of diverse RNA structures and activities, and eventually, of th...
Harutyun Sahakyan, Y. Wolf, E. Koonin· bioRxiv· 0 citations
A mechanistic generative model for bipartite gene-sharing networks that jointly predicts the degree distributions of genes and genomes from three fundamental processes: horizontal gene transfer, functional innovation, and organismal innovation is presented.
Jaime Iranzo, Pedro Jódar, E. Koonin et al.· Proceedings of the National...· 0 citations
A mathematical model of tumor growth under fluctuating conditions with stochastic phenotypic epithelial-mesenchymal switch as the main mechanism of adaptation is developed, and non-trivial evolutionary outcomes are revealed, depending on the relative time scales of the underlying processes.
Sanasar G. Babajanyan, Y. Wolf, R. Canevarolo et al.· bioRxiv· 0 citations
The immortalized non-tumorigenic breast epithelial cell line (MCF10A) develops neoplastic clones under fluctuating conditions in-vitro that mimic the harsh tumor microenvironment and is identified as a potential therapeutic target against epithelial-mesenchymal plasticity and metastatic spread in breast cancer.
Erez Persi, Rafael R. Canevarolo, P. Sudalagunta et al.· Research Square· 1 citation
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