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E. Koonin

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Open access Aug 2026

Loss of replication and transcription systems accompanying transition to nucleus-dependent replication in “Ariadnavirales”, a proposed new order in nucleocytoviricot class Megaviricetes

Sicyoidochytrium minutum DNA virus (SmDNAV) was isolated several years ago from a protist host of family Thraustochytriaceae of the class Labyrinthulomycetes. This virus shared little similarity to other viruses in gene content and protein sequences, albeit seemingly belonging to the phylum Nucleocytoviricota. By exten...

N. Yutin, Y. Wolf, M. Krupovic et al. · 0 citations
#protein folding Open access Sep 2026

Computational modeling of an RNA-peptide world

It is hypothesize that the RNA world was, actually, an ‘RNA-peptide world’, in which, from the earliest stages of evolution, evolving RNA molecules interacted with short random peptides synthesized in a non-templated manner, which could drive the evolution of diverse RNA structures and activities, and eventually, of th...

Harutyun Sahakyan, Y. Wolf, E. Koonin · 0 citations
Open access Jul 2026

A generative model for bipartite gene-sharing networks

A mechanistic generative model for bipartite gene-sharing networks that jointly predicts the degree distributions of genes and genomes from three fundamental processes: horizontal gene transfer, functional innovation, and organismal innovation is presented.

Jaime Iranzo, Pedro Jódar, E. Koonin et al. · 0 citations
Open access Aug 2026

Evolutionary implications of phenotype switching for growth and survival of tumors in stochastic environments

A mathematical model of tumor growth under fluctuating conditions with stochastic phenotypic epithelial-mesenchymal switch as the main mechanism of adaptation is developed, and non-trivial evolutionary outcomes are revealed, depending on the relative time scales of the underlying processes.

Sanasar G. Babajanyan, Y. Wolf, R. Canevarolo et al. · 0 citations
Open access Jul 2026

Fluctuating environment causes neoplastic transition and epithelial-mesenchymal plasticity in human cells

The immortalized non-tumorigenic breast epithelial cell line (MCF10A) develops neoplastic clones under fluctuating conditions in-vitro that mimic the harsh tumor microenvironment and is identified as a potential therapeutic target against epithelial-mesenchymal plasticity and metastatic spread in breast cancer.

Erez Persi, Rafael R. Canevarolo, P. Sudalagunta et al. · 1 citation

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