E. Hernández-Rodríguez

Identification of Natural Flavonoids Targeting PLK-1 as Potential Anti-Metastatic Agents: A Computational Approach

This study combines ligand- and structure-based in silico strategies to predict the inhibitory activity of natural flavonoids on the Polo-Like Kinase-1 (PLK-1) enzyme as candidate anticancer agents, offering a robust methodological framework for proposing candidates with a higher probability of success in subsequent stages of experimental validation, reducing time and costs in the early stages of drug development.