Background Dysregulated innate immunity contributes to COVID-19 severity, but its evolution over the periods of the pandemic is undefined. The aim of the study was to compare ex vivo innate immune responses in COVID-19 and non-COVID-19 community-acquired pneumonia (CAP) and assess associations with pandemic period, sev...
Stavroula-Porfyria Chachali, S. Foutadakis, N. Antonakos et al.· Annals of Intensive Care· 0 citations
BACKGROUND
The ACCESS randomized double-blind controlled trial in hospitalized adults with community-acquired pneumonia (CAP) showed that adding clarithromycin to standard-of-care therapy accelerated clinical recovery within the first 72 hours after the commencement of treatment and reduced progression to organ dysfunc...
Emmanouil Stylianakis, K. Tsiakos, Georgios Niotis et al.· Chest· 0 citations
Extensive divergence was observed in the metabolomic landscape of patients with COVID-19 or CAP, underscoring the disease-specific metabolic adaptations and providing potential targets for diagnostic and therapeutic development.
Vassiliki Rapti, S. Foutadakis, Nikolaos Kakavoulis et al.· Critical Care Explorations· 1 citation· ⚡1
Although targeted modulation of inflammasome pathways represents a promising therapeutic strategy, further research is needed to refine patient selection, identify reliable biomarkers, and better characterise disease heterogeneity to enable successful clinical translation.
Caroline Neumann, Florian Hickl, Julia Kemnitzer et al.· Critical Care· 0 citations
SAILR is identified as a central regulator in linking macrophage survival to host-pathogen interaction and disease pathophysiology, and interacts with the antiapoptotic adaptor protein 14-3-3β to support macrophage survival.
A. Westermann, Alexandra Schock, Diyaa Al Din Ashour et al.· Proceedings of the National...· 2 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
