Open access
Oct 2026
Fenofibrate enhances systemic antitumor efficacy of high- and low-dose radiotherapy plus PD-1 blockade through CD8+ T-cell metabolic reprogramming and LDRT tumor conditioning.
Radiotherapy (RT) combined with PD-1/PD-L1 blockade can induce systemic antitumor responses, but robust control of distant lesions remains uncommon. We identified a quadruple regimen combining immunogenic hypofractionated RT (hRT; 8 Gy × 3) to the primary tumor, low-dose RT (LDRT; 3 Gy × 3) to the secondary tumor, anti...
Mei-Dan Wang, Li-Qun Wang, Sagar et al.
· Cancer Letters · 0 citations