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Open access Aug 2026

Design and Synthesis of 1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one Derivatives as a Selective Inhibitor for Acetylcholinesterase and Butyryl Cholinesterase

Quinoxaline-based heterocycles are of interest as potential cholinesterase inhibitors, and this study evaluated a substituted 1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one series against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The objective was to synthesise and characterise derivatives with...

F. Taiwo, O. B. Omoyeni, I. Olawuni et al. · 0 citations
Open access Aug 2026

Synthesis, Characterization and Antidiabetic Studies of Sulfonamide Derivatives

The treatment of 4-Amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide (1) with substituted aromatic aldehydes and ketones in absolute ethanol with 2-3 drops of glacial acetic acid as a catalyst under reflux conditions afforded Schiff bases of sulfonamide derivatives (1a-1f) with yields ranging from 84% to 95%. Detailed...

F. Taiwo, O. B. Omoyeni, K. Faloye et al. · 0 citations

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