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Author

E. Engelberg-Cook

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4 papers indexed here

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Oct 2026

Generalizing Amyloid β Pathology from Postmortem Human Brains with Vision Foundation Models for Lesion Quantification

By replacing empirical, from-scratch architectures with a generalizable foundation model adapter framework, ViTamyloid provides a highly sensitive scalable digital pathomics toolkit, offering objective, quantitative endpoints for Alzheimer's disease clinical trials and disease subtyping.

Y. Chen, B. D. Boon, E. Engelberg-Cook et al. · 0 citations
Open access Aug 2026

The UNC13A cryptic exon associates with cognitive impairment in Alzheimer’s disease

TAR DNA-binding protein of 43 kDa (TDP-43) is often found in the brains of patients with Alzheimer’s disease (AD), where it co-occurs with amyloid β plaques and tau neurofibrillary tangles, and associates with accelerated cognitive decline and brain atrophy. TDP-43’s function of repressing the inclusion of cryptic exon...

Madison M. Reeves, Sara Aviles Carpintero, M. Zanovello et al. · 0 citations
Open access Sep 2026

TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease

Co‐pathologies – including Lewy body, vascular, and TDP‐43 lesions – are common in Alzheimer's disease (AD), contributing to its clinical and pathological heterogeneity. Genetic risk factors may drive mixed pathology presentation, but their influence on the development of specific co‐pathologies remains unclear.

Madison M. Reeves, Anna Calliari, Tiffany W. Todd et al. · 0 citations
Open access Sep 2026

Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities

Using single-nucleus RNA sequencing across 109 human and 22 mouse samples spanning dorsal and ventral striatum, a comprehensive atlas of subregional neuronal specialization is provided, suggesting divergent pharmacological targets, connectivity, and disease mechanisms.

Raleigh M. Linville, Benjamin T. James, K. Galani et al. · 2 citations · ⚡1

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