Author

E. E. Natasha

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Open access Sep 2026

Disrupting peripheral serotonin synthesis drives sex-specific alterations in sociability and cognition, and reshapes the gut-immune-brain axis.

A role for peripheral 5-HT in behavioral regulation is supported and cross-system associations consistent with sex-specific modulation along the gut-immune-brain axis are revealed, while identifying TPH1-dependent signaling as a potential contributor to neuropsychiatric disorders' pathophysiology is identified.

Rogério C. R. Castro, N. Alenina, E. E. Natasha et al. · Brain, behavior, and immunit... · 0 citations

Open access Sep 2026

Tph2 deficiency shapes neurodevelopmental behavioral trajectories through interactions with the maternal environment, sex, and the gut microbiome

It is demonstrated that 5-HT depletion disrupts behavioral neurodevelopmental trajectories via interactions between genetic, environmental, and ecological factors, highlighting the importance of accounting for sex, environment, and developmental timing in translational research.

Marta C. F. Samina, Rogério C. R. Castro, Thijs Lodder et al. · Translational Psychiatry · 0 citations

Open access Aug 2026

From gut to brain: data-driven evidence suggests causal contribution of gut-microbiota to major depressive disorder in humans

This study provides the first data-driven evidence for a potential causal role of gut microbiota in the pathophysiology of depression in humans, and employs state-of-the-art causal inference tools within Judea Pearl's framework.

L. Fehse, A. H. Ribeiro, N. Winter et al. · Gut microbes · 0 citations