Cholinergic-Dependent Metaplasticity in the Amygdala-Insula Pathway During Incubation of Cocaine Craving.
The time-dependent increase in drug seeking during abstinence, termed 'incubation of craving' is believed to play a major role in the persistent risks of relapse. This phenomenon is associated with synaptic plasticity changes across brain structures involved in reward processing, executive functions, emotion regulation...