Author

E. di Angelantonio

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Open access Aug 2026

A proteome-wide association study of cardiovascular diseases in 640,000 participants of multiple ancestries

This study enables study of large-scale proteomics in diverse populations, provides a systematic map of protein associations of cardiovascular diseases, and demonstrates the utility of genetically imputed proteomes for target discovery and experimental validation.

Yu Xu, Douglas P. Loesch, H. Taylor et al. · medRxiv · 0 citations

Open access Jul 2026

Beyond the classical plasma secretome: genetic architecture and disease associations of the expanded human plasma proteome in 13,445 Europeans

Circulating plasma proteins are key biomarkers and therapeutic targets, now measurable at scale through high-throughput technologies, yet whether expanding proteomics platforms beyond the classical plasma secretome enhances genetic discovery and causal inference remains poorly understood. Here, we use an expanded SomaS...

S. Cadiou, E. Konig, A. Mapelli et al. · medRxiv · 0 citations

Open access Jul 2026

Arrhythmic Risk in Carriers of Predicted Deleterious Rare Variants in Dilated and Arrhythmogenic Cardiomyopathy Genes

PDrV carriers have a higher risk of severe cardiac events, even without a clinical overt disease phenotype at baseline evaluation, and PDrV in arrhythmic genes significantly influence SCD/MVA risk, regardless of phenotypic diagnosis of DCM.

I. Gandin, A. Vergani, M. Massi et al. · JACC: Advances · 0 citations