Open access
Aug 2026
PARP inhibition attenuates neuroinflammation and demyelination in a rat model of multiple sclerosis: A longitudinal [11C]PBR28 TSPO PET imaging study
Poly(ADP-ribose) polymerase (PARP) plays important role in DNA repair, but is also involved in other cellular processes. PARP inhibition was suggested to suppress inflammatory signaling and has been proposed as potential treatment for neuroinflammatory disorders like multiple sclerosis. Yet, its effects on lesion-assoc...
Ge Li, Inês F. Antunes, Zihe Ming et al.
· Neurotherapeutics · 0 citations