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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

E. Casals

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Open access Oct 2026

Pdk1-dependent metabolic heterogeneity promotes aggressive colorectal cancer through cell-intrinsic interferon signaling

Tumor heterogeneity is a major determinant of tumor progression and therapeutic resistance, yet the contribution of metabolism to intratumoral heterogeneity still remains poorly explored. Here, we find that pyruvate dehydrogenase kinase-1 (Pdk1) expression defines metabolically distinct cancer cell populations in color...

Jessica Calviello, Lisa Pöltl, Alessia Mira et al. · 0 citations
Open access Jul 2026

PI3K signaling promotes inflammatory tumor-macrophage crosstalk associated with mesenchymal glioblastoma

This work identifies PI3K signaling as a central regulator integrating vascular remodeling with inflammatory tumor-macrophage communication in mesenchymal glioblastoma and provides a mechanistic framework linking PI3K signaling, macrophage education and the MES phenotype.

Rebeca Burgos-Panadero, María Rosado-Sanz, V. Montosa-i-Micó et al. · 0 citations

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