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Open access 2026

Integrated pathway analysis of small cell lung cancer: NOTCH alterations as an independent favorable prognostic factor and DNA damage repair alterations as correlates of tumor mutational burden

Aim: Small cell lung cancer (SCLC) is characterized by near-universal TP53/RB1 inactivation and high mutation burden, yet prognostic biomarkers beyond clinical stage remain limited. This study aimed to characterize pathway-level genomic alterations—including DNA damage repair (DDR), NOTCH, mismatch repair (MMR), and MY...

E. Camoz, C. Karaçin · 0 citations

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