BACKGROUND
Although commonly accepted depressive subtypes reflect phenotypic differences, there has been minimal progress in identification of discrete pathophysiological pathways, biomarkers or differential therapeutic approaches to effectively guide clinical management.
AIMS
To test the biological validity and clin...
E. Tonini, J. Crouse, M. Shin et al.· The British journal of psych...· 1 citation
CRD-load was associated with clinical symptoms, functional impairment, and mood-related genetic liability, and these findings support further evaluation of brief assessments of circadian-associated phenotypes for identifying young people at greater clinical burden and informing circadian-focused prevention and early in...
M. Shin, E. Tonini, J. Carpenter et al.· medRxiv· 0 citations
Internalising symptoms including depression, anxiety and somatic symptoms in adolescence are common. They can be transient, but they can also persist and progress to major depressive disorder (MDD) Polygenic risk scores for major depression (MD-PGS) may help identify which symptomatic adolescents are at greatest risk o...
E. Byrne, Nathan A. Gillespie, J. Najman et al.· Molecular Psychiatry· 0 citations
The association between irregular cycles and depression, and between long cycles and depression and anxiety, strengthened significantly with increasing gynaecologic age, while symptom burden associations were consistent throughout the post-menarcheal period.
Sushma Marla, S. Gangaraju, Josh Nguyen et al.· European Child and Adolescen...· 0 citations
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