Author

E. Bria

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Open access Sep 2026

Early termination of clinical trials enrolling patients with breast cancer: Reasons, determinants, and temporal patterns

Background The occurrence of clinical trial termination before planned completion (or “early termination” [ET]) remains poorly characterized in the breast cancer field. This study investigates the reasons, determinants, and temporal patterns of ET in breast cancer trials. Methods We conducted a cross-sectional study us...

G. M. Iannantuono, G. Daniele, Luca Mastrantoni et al. · Breast · 0 citations

Open access Oct 2026

Clinical Utility of Broad-Panel Profiling in Non-Small Cell Lung Cancer: Pairwise Co-Mutational Gene Patterns and PD-L1 Associations Define Stage-Specific Prognosis

Objectives: Precision medicine has improved outcomes in advanced lung cancer, but its implementation remains limited. The prospective LANTERN project (NCT05802771) involves comprehensive clinical and multi-omics data collection. Here, we report preliminary genomic findings, focusing on the prognostic impact of gene mut...

C. Sassorossi, E. De Paolis, Jessica Evangelista et al. · Genes · 0 citations

Open access Sep 2026

Osimertinib in advanced non-small cell lung cancer (NSCLC) harboring different EGFR uncommon variants: real-world data from the Italian biomarker ATLAS database

Osimertinib exhibited meaningful differences in efficacy and resistance mechanisms across distinct ucEGFR mut, and ex19 delins showed comparable survival outcomes and resistance patterns to classical ex19 deletions, albeit with heterogeneous osimertinib sensitivity depending on the deletion–insertion starting codon.

G. Farinea, A. Mogavero, A. Vitale et al. · ESMO Open · 0 citations