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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

E. Bouřa

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Open access Sep 2026

Characterization of the N7 RNA cap methyltransferase from Trichomonas vaginalis and inhibitor discovery

RNA cap formation is essential for eukaryotic gene expression, yet the enzymes responsible for cap methylation remain poorly characterized in many eukaryotic parasites, including Trichomonas vaginalis. Here, we functionally and structurally characterized the RNA guanine-N7 methyltransferases (MTases) from T. vaginalis,...

J. Benýšek, D. Chalupska, Milan Štefek et al. · 0 citations
Open access Oct 2026

The Golgi-resident protein ACBD3 facilitates the interaction between enteroviral 3A proteins and Exportin-1.

Enteroviruses are among the most common viral pathogens in humans, causing illnesses ranging from the common cold to severe and sometimes life-threatening diseases such as acute haemorrhagic conjunctivitis or poliomyelitis. To replicate efficiently within host cells, enteroviruses hijack several host factors, including...

Vladimira Horova, Michala Zgarbová, M. Klíma et al. · 0 citations
Open access Aug 2026

First-in-class inhibitors of the protein lysine methyltransferase METTL21A.

A crystal structure of METTL21A is solved in complex with 6m, providing structural insight into ligand recognition and supporting further structure-guided optimization and establishing a biochemically and structurally validated starting point for probing METTL21A function and a foundation for the development of cellula...

Hugo Kocek, Michal Vaško, M. Dejmek et al. · 0 citations

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