Author

E. Bignon

2 papers indexed here

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Sep 2026

From Photoswitch to Polycycle: Structure-Reactivity Relationships in the Photoinduced Isomerization-Cyclization of Amino(hetero)arylidene-thiazolidine-2,4-diones.

We report a comprehensive study of the photoinduced isomerization-cyclization cascade of o-amino(hetero)arylidenethiazolidine-2,4-diones (Het)Ar-TZDs 1, combining computational, synthetic, and kinetic investigations. Time-dependent density functional theory (TD-DFT) calculations were used to predict absorption maxima a...

Vincent Bruneau, Johanne Coutard, Nina Bukhtiiarova et al. · Chemistry · 0 citations

Open access Aug 2026

Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers

Metabolic reprogramming is a defining feature of cancer; however, how it contributes to therapeutic resistance remains incompletely understood. Here we show that loss of aldo-ketoreductase 1A1 (AKR1A1) in renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) disrupts terminal glycolytic flux and lactate product...

Chiara Pecorari, Mojca Bratina, Evelyn Gonzalez et al. · Nature Communications · 1 citation