Aging Reduces Basal Cholinergic Reserve, but the Pattern of Scopolamine-Induced Memory Impairment Remains Comparable in Rats.
BACKGROUND Experimental models of cognitive dysfunction are essential for investigating mechanisms of memory impairment and therapeutic strategies. The scopolamine-induced memory impairment (SIMI) model is widely used for inducing acute cholinergic dysfunction and related cognitive deficits. However, using young animal...