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Author

Dylan Klein

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Open access Jul 2026

A Label-Free Multi-Metric Pipeline for Benchmarking Single-Cell RNA-Sequencing Clustering and Testing the Reproducibility of Cell-Type Heterogeneity

A label- free, multi-metric pipeline is presented that reframes clustering as an auditable, methods-blind decision and separates two notions of stability that are commonly conflated: reproducibility under cell resampling (bootstrap) and reproducibility under re-embedding (retraining the representation).

Zachary Yousef, Jonah Simone, Dylan Klein et al. · 0 citations

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