Dylan Ashraf

Target-family differences in stereochemical discrimination: a same-assay analysis of enantiomer pairs in ChEMBL

Chiral molecules can differ substantially in biological potency, yet the extent to which this stereochemical discrimination varies across protein families has not been systematically measured. Here, same-assay enantiomer pairs were extracted from ChEMBL 37 to construct an archive-scale, target-family-stratified distrib...