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Review Open access Sep 2026

DiagnosticXchange: an open-source framework for evaluating safety, efficiency, and diagnostic reasoning in clinical AI systems.

OBJECTIVE To develop and validate an open-source evaluation framework that assesses clinical AI diagnostic systems across multiple clinically relevant dimensions (accuracy, cost, time, invasiveness, physician effort, and safety behaviors), addressing the limitations of accuracy-only benchmarks. MATERIALS AND METHODS...

M. Sorka, A. Gorenshtein, H. Abramovitch et al. · 0 citations
Open access Sep 2026

Tumor immune microenvironment remodeling predicts response to checkpoint inhibitor therapy.

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, yet the basis of variable patient responses remains unclear. We assemble a longitudinal single-cell RNA sequencing atlas of 441 samples from 241 patients across ten cancer entities to map treatment-associated remodeling of the tumor immune microenviro...

Zhongyang Lin, Mitalee Chandra, Nalini Srinivas et al. · 1 citation

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