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Duan-Qing Pei

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Open access Aug 2026

In vivo multimodal lineage tracing of mammalian development by DeepTrack barcoding

DeepTrack is presented, a lineage tracing mouse model that integrates in situ cellular barcoding with high-throughput, single-cell multi-omics to simultaneously profile clonal fates, transcriptomic states, and chromatin accessibility and provides a versatile framework for decoding multimodal regulation of cell fate acr...

Chen-Yu Guo, Jun-Yao Jiang, Xiao-Min Wang et al. · 0 citations
Open access Aug 2026

Distinct regulation of Wnt signaling and EPZ5676 governs human UiPSM reprogramming via the CDX2/T/TBX6 core axis

It is shown that Wnt/β-catenin signaling coordinates UiPSM reprogramming and maintenance via the CDX2/T/TBX6 axis, which offers new mechanistic understanding of human mesoderm lineage specification and somatic cell reprogramming.

Kaipeng Wang, Xingnan Huang, Huiru Gao et al. · 0 citations
Jul 2026

A fast 2C-induction method reveals a barrier role of SP2 for totipotency

This study has established a highly efficient in vitro model for totipotency induction and highlighted molecular barriers shaping cell fate decisions, providing a platform to dissect the mechanisms governing the pluripotency-to-totipotency transition.

Siling Hu, Ping-Hui Zhu, He Liu et al. · 0 citations

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