The many faces of the Sigma-1 Receptor: Pathogenic variants reveal the structural determinants of ligand recognition and oligomeric interface organization
The Sigma-1 receptor (S1R) is a ligand-regulated membrane protein whose pathogenic variants are associated with motor-neuron and neurodegenerative disorders, yet its ligand conformational selectivity and receptor organization remain incompletely understood. We systematically characterized 35 pathogenic or likely pathog...
Nikola Mitović, Nina Japundžić‐Žigon, Marija Stanojević et al.
· Zenodo (CERN European Organi... · 0 citations