Indole, a prominent bicyclic heteroaromatic scaffold, has attracted significant attention
due to its wide-ranging biological, pharmaceutical, and industrial relevance. This review summarizes
key advancements made between 2014 and 2025 in the green synthesis of indole derivatives, emphasizing
the growing importance...
Ashish Patel, Dharti Patel, Krishi Patel et al.· Mini-Reviews in Organic Chem...· 0 citations
INTRODUCTION
Angiogenesis, primarily controlled by Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2), significantly influences tumor growth and metastasis. Consequently, VEGFR-2 targeting has emerged as an important strategy for cancer treatment. Owing to their known efficacy as strong tyrosine kinase inhibitors,...
A. Yadav, Drashti Shah, Princy Desai et al.· Current Drug Targets· 0 citations
These findings demonstrate that mechanochemically synthesized THPM scaffolds represent highly promising lead structures for sustainable anti-TB drug discovery.
Drashti Shah, Ashish Patel· Russian journal of bioorgani...· 0 citations
This comprehensive review critically summarizes advances from 2021-2025 in the design of selective PI3K inhibitors based on the 1,3,5-triazine (s-triazine) scaffold, emphasizing how its symmetric 2/4/6 substitution vectors, electron-deficient hinge-binding profile, and modular cyanuric chloride - enabled SNAr synthesis...
